PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4095)
Related Products (4095)
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PROTAC Linkers Isoform Comparison
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4-(1-(tert-Butoxycarbonyl)azetidin-3-yl)benzoic acid
0 ImagesCat. No.: HY-W107461CAS No.: 908334-10-1
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tert-Butyl (2-(chlorosulfonyl)ethyl)carbamate
0 ImagesCat. No.: HY-W613493CAS No.: 134019-73-1
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3-(1-((Benzyloxy)carbonyl)piperidin-4-yl)propanoic acid
0 ImagesCat. No.: HY-W024030CAS No.: 63845-33-0
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DBCO-PEG3-Gly
0 ImagesCat. No.: HY-W1130399
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4-Amino-cyclohexanecarboxylic acid methyl ester hydrochloride
0 ImagesCat. No.: HY-W298180CAS No.: 100707-54-8
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2-(4-((tert-Butoxycarbonyl)amino)cyclohexyl)acetic acid
0 ImagesCat. No.: HY-W259625CAS No.: 344933-31-9
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N'-Boc-N-(Gly-Oleoyl)-Lys
0 ImagesCat. No.: HY-141291CAS No.: 2353409-71-7
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Propargyl-(trans)-cyclohexanediamine-Boc
0 ImagesCat. No.: HY-W038812CAS No.: 1313279-47-8
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Methyl 6-(chlorosulfonyl)hexanoate
0 ImagesCat. No.: HY-W198960CAS No.: 1202760-84-6
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Mal-NH-PEG12-CH2CH2COOPFP ester
0 ImagesCat. No.: HY-130864CAS No.: 2136296-33-6
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1,4-Phenylenedimethanamine dihydrochloride
0 ImagesCat. No.: HY-W140538CAS No.: 3057-45-2
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Heptacosanedioic Acid
0 ImagesCat. No.: HY-W674306CAS No.: 5638-06-2
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6-Bromohexanoyl Chloride
0 ImagesCat. No.: HY-W540231CAS No.: 22809-37-6
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tert-Butyl (2-((tert-butyldimethylsilyl)oxy)ethyl)carbamate
0 ImagesCat. No.: HY-W068370CAS No.: 203738-69-6
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Sebacic acid monomethyl ester
0 ImagesCat. No.: HY-W150022CAS No.: 818-88-2
![PIP-C-3-Azaspiro[5.5]undecane-boc](https://file.medchemexpress.com/product_pic/hy-161656.gif "Click to View PIP-C-3-Azaspiro[5.5]undecane-boc Product Detail")
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Tert-butyl (4-((tert-butoxycarbonyl)amino)phenethyl)carbamate
0 ImagesCat. No.: HY-W353135CAS No.: 1823291-67-3
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Fmoc-NH-PEG15-CH2CH2COOH
0 ImagesCat. No.: HY-133361CAS No.: 2378590-46-4
